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DOLICHOL, AGING and COVID-19: Hijack of the century!
It's time to make lowering your cholesterol a PRIORITY! It's Wednesday and I hope you don't mind if I ramble about science for a bit! There's some information that has had me scratching my head since this pandemic took over. That is, why is this virus, COVID-19, more attracted and mortal to the elderly, obese, males and people with underlying heart conditions? What I've discovered has had a pretty significant impact on my knowledge around our susceptibility to infection. Listen for a moment to my theory. There is a substance that increases in concentration with age, is widely distributed within the cell, tissues and organelles, and may correlate with the amount of cholesterol in the blood, which is a significant risk factor for heart disease. This substance is called DOLICHOL. Dolichol is among the largest lipids in the cell. There are several reasons why my interest concerning this molecule has been peaked. First, dolichol has been described by Parentini et. al. as meeting the criteria to be defined as a biomarker for aging. For our elementary purposes, the researchers suggest that the levels of dolichol relate directly to age in all tissues and are not changed by several age-dependent diseases in the same direction as that of aging and, secondly, it's accumulation is due to metabolic changes of aging.(1) Secondly, low-density proteins (LDL), also known as bad cholesterol, is a transporter of dolichol in the bloodstream, in addition to being associated with the accumulation of dolichol intermediates during aging and certain diseases.(3) Thirdly, a study involving the daily use of anabolic androgenic steroid use decreased serum dolichol levels and increased ubiquionone levels.(4) For the record, steroids have been used in the treatment of patients with COVID-19. Finally, the connection in this whole labyrinth, is that, DOLICHOL, is a substrate for n-linked glycosylation. (5) As you know viruses do not have their own machinery to replicate and reproduce on their own, they exploit host-cell machinery to glycosylate their own proteins during replication, thus, utilizing n-linked glycosylation for important biological functions. (6) I propose that in decreasing this substrate , dolichol through cholesterol reduction, naturally and organically, we can decrease the opportunistic exploits of this virus from gaining entry and wreaking havoc in our bodies. We welcome your scientific feedback. Please leave a comment with your thoughts and commentary. Stay Healthy and Stay Safe, Chandra Nicole Natural Products Many products out there promise the benefit of lowering cholesterol through the use of red yeast rice products. I would suggest that in your selection, especially if you are not currently taking a statin medication, that you do your research to make sure that the product, also has liver protection, such as those that cleanse and protect the liver, as monocol K, and many of these medications cause liver damage in some people. Take a look at CHOLESLO*, a product I have been reviewing and researching, and see if it is a good fit for you. Leave a review and let me know your thoughts. I want to hear from you! * As with all information, products & services, results are not guaranteed and will vary from one individual to another. It’s unknown if the presence of an ingredient will impede the efficiency of another. Please consult with your doctor. Statements made, or products sold through this web site, have not been evaluated by the Food and Drug Administration They are not intended to diagnose, treat, cure, or prevent any disease. References 1. Parentini I, Cavallini G, Donati A, Gori Z, Bergamini E. Accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of aging. J Gerontol A Biol Sci Med Sci. 2005;60(1):39-43. doi:10.1093/gerona/60.1.391. 2. Shiota Y, Kiyota K, Kobayashi T, et al. Distribution of dolichol in the serum and relationships between serum dolichol levels and various laboratory test values. Biol Pharm Bull. 2008;31(3):340-347. doi:10.1248/bpb.31.340 3. Rip JW, Blais MM, Jiang LW. Low-density lipoprotein as a transporter of dolichol intermediates in the mammalian circulation. Biochem J. 1994;297 ( Pt 2)(Pt 2):321-325. doi:10.1042/bj2970321 4. Karila T, Laaksonen R, Jokelainen K, Himberg JJ, Seppälä T. The effects of anabolic androgenic steroids on serum ubiquinone and dolichol levels among steroid abusers. Metabolism. 1996;45(7):844-847. doi:10.1016/s0026-0495(96)90157-2 5. Burda P, Aebi M. The dolichol pathway of N-linked glycosylation. BBA - General Subjects. 1999;1426(2):239-257. doi:10.1016/S0304-4165(98)00127-5. 6. Watanabe Y, Bowden TA , Ian A. Wilson IA, Crispina M. Exploitation of glycosylation in enveloped virus pathobiology. BBA - General Subjects. 2019;1863(10): 1480-1497
CHOLESTEROL and COVID-19: The Benefit of Red Yeast Rice
It's time to make lowering your cholesterol a PRIORITY! Over the past year I have been looking at healthy, natural ways of lowering cholesterol, which is the leading cause of Cardiovascular Disease. I was surprised to come across a natural product called, red yeast rice. I am sure you have heard of statins, right? Well, red yeast rice produces a significant amount of monacolin K, which is identical, chemically, to the active ingredients of these manufactured drugs. So, why is there not a push or promotion to consume this natural product vs. a prescribed medication? I will let you decide the answer for yourself. Rationale for Change In my review of literature, I came across a meta-analysis of 13 randomized, placebo-controlled trials containing 804 participants that concluded that red yeast rice is effective and relatively safe approach for dyslipidemia. (1) Dyslipidemia is the abnormal levels of lipids, cholesterols, in the blood. This condition leads to all kinds of predispositions to certain medical conditions, such as, atherosclerosis (clogged arteries), stroke (interruption of blood supply to the brain), cardiovascular disease (coronary heart disease and heart attack) and a number of cancers. (2, 3) I would even argue, based on more recent research, which suggests that high cholesterol adds to susceptibility to viral disease and mortality from complications of viral disease. This being said it is adamant and of high priority, especially in light of the disproportionate mortality rate of patients infected with COVID-19 and comorbidities such as obesity and heart disease, that we pay attention to our cholesterol levels. (4, 5) Natural Products Many products out there promise the benefit of lowering cholesterol through the use of red yeast rice products. I would suggest that in your selection, especially if you are not currently taking a statin medication, that you do your research to make sure that the product, also has liver protection, such as those that cleanse and protect the liver, as monocol K, and many of these medications cause liver damage in some people. Take a look at CHOLESLO*, a product I have been reviewing and researching, and see if it is a good fit for you. Leave a review and let me know your thoughts. I want to hear from you! Stay Healthy and Stay Safe, Chandra Nicole * As with all information, products & services, results are not guaranteed and will vary from one individual to another. It’s unknown if the presence of an ingredient will impede the efficiency of another. Please consult with your doctor. Statements made, or products sold through this web site, have not been evaluated by the Food and Drug Administration They are not intended to diagnose, treat, cure, or prevent any disease. References 1. Li Y, Jiang L, Jia Z, Xin W, Yang S, et al. (2014) A Meta-Analysis of Red Yeast Rice: An Effective and Relatively Safe Alternative Approach for Dyslipidemia. PLoS ONE 9(6): e98611. doi:10.1371/journal.pone.0098611 2. Lin CJ, Lai CK, Kao MC, et al. Impact of cholesterol on disease progression. Biomedicine (Taipei). 2015;5(2):7. doi:10.7603/s40681-015-0007-8 3. Andersen CJ. Impact of Dietary Cholesterol on the Pathophysiology of Infectious and Autoimmune Disease. Nutrients. 2018;10(6):764. Published 2018 Jun 13. doi:10.3390/nu10060764 4. Radenkovic D, Chawla S, Pirro M, Sahebkar A, Banach M. Cholesterol in Relation to COVID-19: Should We Care about It?. J Clin Med. 2020;9(6):E1909. Published 2020 Jun 18. doi:10.3390/jcm9061909 5. Xie Y, You Q, Wu C, et al. Impact of Cardiovascular Disease on Clinical Characteristics and Outcomes of Coronavirus Disease 2019 (COVID-19) [published online ahead of print, 2020 Jun 13]. Circ J. 2020;10.1253/circj.CJ-20-0348. doi:10.1253/circj.CJ-20-0348
July's BabeBox! Perfect for Summer Inspired Looks!
Don't you love surprises? what do you get? you get full-sized products! that means, no more samples, travel-size and deluxe-size products. All of the babebox products are full-sized, premium & cruelty-free. $80+ value every babebox is guaranteed to have over $80 in value. we source our products from indie & big beauty brands that are cruelty-free certified. 100% Cruelty-Free Cosmetics every 4-6 weeks...WATCH THE VIDEO BELOW AND CLICK HERE! Tried the babebox? Let me know your thoughts.
I loved the way this product embellished my client's 3A, 3B and 3C curls! If you're not familiar with curl patterns, Type 3 hair ranges from loose, buoyant loops to tight, springy corkscrews. These types of curl patterns has lots of sheen, but can be prone to frizziness. Taliah Waajid's Curly Curl Cream added much more shine, control and helped to eliminate most of the frizziness! How I Used This Product: Hair was washed, conditioned and detangled, with conditioner, at the shampoo bowl. A Leave-In was applied to her hair. I prefer REDKEN Extreme line. Hair was left wet and sectioned in four sections. I further sectioned her hair in smaller sections and used my fingers to evenly distribute and to define, shape and style curls. I opted to NOT comb through her hair to maximize the clumping of her natural curls. Because it's cold here in Michigan, I helped the curls dry faster using a diffuser on my favorite hair dryer. \ Ingredients: Water (Aqua), (PEG-75) Shea Butter Glyceride (Butyrospermum Parkii), Glyceryl Stearate, Cetearyl Alcohol, Stearic Acid, Sodium Cocoyl Glucamate, Sodium Polycrylate Ethylhexl Trideceth-6, D&C Caramel 050, Sage Extract (Salvia Officinalis), Caprylyl Glycol Phenoxyethanol, Fragrance (Parfum). How to Maintain: I suggest to ALL of my clients to invest in a Satin Bonnet or Scarf, depending on the style. For styles with a lot of volume, I recommend using the bonnet. To refresh the curls, use Aloe Vera Juice in a spray bottle. Overall Score (1=Worst to 5=Best): I give this product a 4.8. It's a great product, however, the client called a couple days later because her curls dried out. I like products that can hold moisture in the hair a little longer. This is to be expected for most curly girls in the Type 3 and Type 4 range. Chandra Nicole is a licensed cosmetologist based in Garden City, Michigan at Living in Luxury Beauty Spa.
Transitions, transitions, transitions… Transitions are difficult! Let’s face it, they are outright tough! Do you know what’s even more difficult? The feeling of being stagnant and stuck or unproductive in life, relationships, or a career. There’s nothing more unsavory than knowing deep down inside that you were called to do something different, but for the sake of comfortability or to satisfy the script others have for your life, you stand STILL. Tick, tock, tick, tock…. Do you hear that sound of time passing by? Imagine looking back on the last days of your life and knowing that you could have unpackaged the gifts inside of you that could have changed the destiny of those around you, like your children, your spouse, your friends. Perhaps, someone you never had the chance to meet had a date on your destiny calendar that never came to pass because you were [sigh]comfortable. Fear of the unknown has gripped many of us so tightly that we refuse to let our minds take us to the place of…DESTINY. We fear failure, rejection, scrutiny! We’ve become people pleasers and slaves to our own negative thinking. Sometimes, our biggest foe is our own thoughts. Here’s some hard truth…we very well may fail. We most certainly may get rejected, and someone, somewhere is going to study what we’re doing with critical eyes. Knowing these truths and pushing past these fears will set you FREE. Let the momentum of “what could have” move you today. Take that first step towards unleashing that thing that’s burning in your belly. You’ve tried to lay it aside, but it just won’t go away. Maybe you dream about it. Maybe there have been signs and wonders. Now is the time to move forward. Tomorrow is not promised to you and someone needs what has been placed inside of you to AFFECT your family, your community and this world. Get unstuck today!
On the surface, we're taught that "HAIR is HAIR" and that hair is a protein that just comes out of your scalp. However, the moment you decide that you are not going to limit yourself to one ethnicity, you quickly learn that hair varies tremendously from one ethnicity to another and, even from person to person in the same families. Conducting a 5C Consultation is first step your stylist takes in providing the best hair care experience and products to meet your needs. Hair Typing, Why We Do It? I love hair!! All kinds! Coiled, straight, stringed…I love it! However, your hair may not LOVE every product! There are 5 basic characteristics I look at to determine which products work best on your hair and if your hair can handle or needs a specific service or treatment. They include: Curl Pattern-How much curl each strand has, i.e. STRAIGHT, WAVY, CURL/COIL, ZIGZAG Texture-Thickness of each hair strand, i.e. FINE, MEDIUM, COARSE Porosity-Flatness of the cuticles on each strand, i.e., cuticles lay flat and repel water with low porosity vs. cuticles do not lay flat and takes a long time to dry with high porosity Density-Number of hairs on your head Health –State of each strand and scalp So, without a GREAT consultation, you may not have a GREAT salon experience!! To find out what questions I ask during my New - Client 5C Consultation: Improving Your Experience, check out my survey here at: Here's to GREAT HAIR! KEEP CALM and BOOK ME! Call me at (734) 237-6770 or visit . Chandra Nicole
We’ve made it quick and convenient for you to manage your blog from anywhere. In this blog post we’ll share the ways you can post to your Wix Blog. Blogging from Your Wix Blog Dashboard On the dashboard, you have everything you need to manage your blog in one place. You can create new posts, set categories and more. To head to your Dashboard, open the Wix Editor and click on Blog > Posts. Blogging from Your Published Site Did you know that you can blog right from your published website? After you publish your site, go to your website’s URL and login with your Wix account. There you can write and edit posts, manage comments, pin posts and more! Just click on the 3 dot icon ( ⠇) to see all the things you can do. #bloggingtips #WixBlog
When it comes to design, the Wix blog has everything you need to create beautiful posts that will grab your reader's attention. Check out our essential design features. Choose from 8 stunning layouts Your Wix Blog comes with 8 beautiful layouts. From your blog's settings, choose the layout that’s right for you. For example, a tiled layout is popular for helping visitors discover more posts that interest them. Or, choose a classic single column layout that lets readers scroll down and see your post topics one by one. Every layout comes with the latest social features built in. Readers can easily share posts on social networks like Facebook and Twitter and view how many people have liked a post, made comments and more. Add media to your posts When creating your posts you can: Upload images or GIFs Embed videos and music Create galleries to showcase a media collection Customize the look of your media by making it widescreen or small and easily align media inside your posts. Hashtag your posts Love to #hashtag? Good news! You can add tags (#vacation #dream #summer) throughout your posts to reach more people. Why hashtag? People can use your hashtags to search through content on your blog and find the content that matters to them. So go ahead and #hashtag away!
With Wix Blog, you’re not only sharing your voice with the world, you can also grow an active online community. That’s why the Wix blog comes with a built-in members area - so that readers can easily sign easily up to become members of your blog. What can members do? Members can follow each other, write and reply to comments and receive blog notifications. Each member gets their own personal profile page that they can customize. Tip: You can make any member of your blog a writer so they can write posts for your blog. Adding multiple writers is a great way to grow your content and keep it fresh and diversified. Here’s how to do it: Head to your Member’s Page Search for the member you want to make a writer Click on the member’s profile Click the 3 dot icon ( ⠇) on the Follow button Select Set as Writer